• New Strategy For Stimulating Autophagy
    on June 30, 2018 at 12:00 am

    New Strategy For Stimulating Autophagy tajouri, Aya salem Autophagy has become a hot topic in recent years, earning its discoverer the Nobel Prize in Physiology and Medicine in 2016. The process involves the rounding up of misfolded proteins and obsolete organelles within a cell into vesicles called autophagosomes. The autophagosomes then fuse with a lysosome, an enzyme-containing organelle that breaks down those cellular macromolecules and converts it into components the cell can re-use. Autophagy is a process in which long-lived proteins, damaged cell organelles, and other cellular particles are sequestered and degraded. This process is important for maintaining the cellular microenvironment when the cell is under stress. Autophagy plays a direct or indirect role in health and disease. A simplified definition of autophagy is that it is an exceedingly complex process which degrades modified, superfluous (surplus) or damaged cellular macromolecules and whole organelles using hydrolytic enzymes in the lysosomes. It consists of sequential steps of induction of autophagy, formation of autophagosome precursor, formation of autophagosome, fusion between autophagosome and lysosome, degradation of cargo contents, efflux transportation of degraded products to the cytoplasm, and lysosome reformation […]

  • The Prevalence Of Intra-Oral Complications In Orthodontic Treatment
    on June 28, 2018 at 12:00 am

    The Prevalence Of Intra-Oral Complications In Orthodontic Treatment Bushwigeer, Sara Salaheddin Orthodontic treatment aims at restoring correct occlusion and chewing function and improving the aesthetics of the dentition and facial esthetics of the patient but like any other treatment modalities, in addition to its benefits, it is also associated with risks and complications, it has the potential to cause significant damage to hard and soft tissues. This repot aims to highlight the prevalence of the main inta-oral complications during orthodontic treatment Orthodontic treatment ensures proper alignment of the teeth and improves the occlusal and jaw relationship. This not only aids in better mastication, speech, and facial aesthetics, but also contributes to general and oral health, thereby improving the quality of life, The most important aspect of orthodontic care is to have an extremely high standard of oral hygiene before and during orthodontic treatment, Because bad oral hygiene will increase the risk of complications However, the most commonly reported adverse effects of orthodontic treatment includes, Root Resorption, tooth discolorations, decalcification, periodontal complications, so It is essential that adequate safety measures are included with this type of treatment. […]

  • Bell’s palsy
    on June 28, 2018 at 12:00 am

    Bell’s palsy Bayou, Khairiah Mohamed Bell's palsy or idiopathic facial paralysis is the most common cause of unilateral facial paralysis. it has specific and important symptoms. it causes is unknown but may be associated with other diseases. This report will discuss the possible causes, symptoms, diagnosis, and the treatment of Bell's palsy Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to the facial nerves. The facial nerve-also called the 7th cranial nerve-travels through a narrow, bony canal (called the Fallopian canal) in the skull, beneath the ear, to the muscles on each side of the face. For most of its journey, the nerve is encased in this bony shell.Each facial nerve directs the muscles on one side of the face, including those that control eye blinking and closing, and facial expressions such as smiling and frowning. Additionally, the facial nerve carries nerve impulses to the lacrimal or tear glands, the saliva glands, and the muscles of a small bone in the middle of the ear .called the stapes. The facial nerve also transmits taste sensations from the tongue When Bell's palsy occurs, the function of the facial nerve is disrupted, causing an interruption in the messages the brain sends to the facial muscles. This interruption results in facial weakness or paralysis […]

  • Peptic ulcer and NSAIDs
    on June 28, 2018 at 12:00 am

    Peptic ulcer and NSAIDs Salem, Fares Non-steroidal anti-inflammatory drugs including low-dose aspirin are some of the most commonly used medicines. They are associated with gastrointestinal mucosal injury. Before prescribing, it is important to assess the patient’s gastrointestinal risk factors such as age and history of peptic ulcers. So this report will discuss the relation between peptic ulcer and NSAIDs Gastroduodenal ulceration and bleeding are the major limitations to the use of nonsteroidal anti-inflammatory drugs (NSAIDs). The development of safer NSAIDs or of effective therapies for the prevention of the adverse effects of existing NSAIDs requires a better understanding of the pathogenesis of NSAID-induced ulcer disease. NSAIDs can cause damage to the gastroduodenal mucosa via several mechanisms, including the topical irritant effect of these drugs on the epithelium, impairment of the barrier properties of the mucosa, suppression of gastric prostaglandin synthesis, reduction of gastric mucosal blood flow and interference with the repair of superficial injury […]